Compatibility Study Between Naproxen and Tablet Excipients Using Differential Scanning Calorimetry

1 January 1990

journal article
research article
Published by Taylor & Francis in Drug Development and Industrial Pharmacy

Vol. 16 (4) , 673-683
https://doi.org/10.3109/03639049009104410

Abstract

Differential scanning calorimetry (DSC) was used to investigate the physico-chemical compatibility between naproxen and a number of commonly used tablet excipients. Interactions of naproxen with PVP, cross-linked PVP, Emcompress and the lubricants stearic acid, magnesium stearate and Precirol Ato 5 were found. Naproxen was found to be compatible with starch, Sta-Rx 1500, Primojel, Explotab, Avicel PH 101, Elcema G250, Ac-Di-Sol and Sterotex.

Keywords

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