The interaction of β‐N‐methylamino‐L‐alanine with bicarbonate: an 1H‐NMR study
- 17 July 1989
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 251 (1-2) , 31-35
- https://doi.org/10.1016/0014-5793(89)81423-1
Abstract
The mode of action of the neurotoxic, non‐protein amino acid β‐N‐methylamino‐L‐alanine (L‐BMAA) is unknown. We have shown, using 1H‐NMR spectroscopy, that L‐BMAA forms a stable adduct with bicarbonate (probably a carbamate). The properties of this adduct may explain the observation that L‐BMAA and N‐methyl‐D‐aspartic acid appear to act at the same central nervous system receptors.Keywords
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