Preparation and production of a cancer chemopreventive agent, Bowman‐Birk inhibitor concentrate
- 1 January 1993
- journal article
- other
- Published by Taylor & Francis in Nutrition and Cancer
- Vol. 19 (3) , 281-302
- https://doi.org/10.1080/01635589309514259
Abstract
We describe our studies to produce an extract of soybeans with anticarcinogenic activity that we believe will be useful as a human cancer chemopreventive agent for several different organs. The anticarcinogenic activity of the extract is thought to be due to chymotrypsin inhibitor activity, which is due to the Bowman‐Birk protease inhibitor (BBI) present in the extract, termed BBI concentrate (BBIC). We describe the contents of BBIC, the ability of BBIC to inhibit malignant transformation in vitro in terms of its chymotrypsin inhibitor activity, and the results of long‐term toxicity studies in which mice and rats were exposed to high levels of BBIC for long periods of time.Keywords
This publication has 35 references indexed in Scilit:
- Effects of various preparations of dietary protease inhibitors on oral carcinogenesis in hamsters induced by DMBANutrition and Cancer, 1993
- Humoral and cellular immune functions are not compromised by the anticarcinogenic Bowman‐Birk inhibitorNutrition and Cancer, 1992
- Acute effects of the Bowman-Birk protease inhibitor in miceToxicology, 1991
- The effects of the Bowman-Birk protease inhibitor on c-myc expression and cell proliferation in the unirradiated and irradiated mouse colonCancer Letters, 1990
- Cell cycle progression of C3H 10T½ and 3T3 cells in the absence of an increase in c-myc RNA levelsCarcinogenesis: Integrative Cancer Research, 1988
- Chymotrypsin-specific protease inhibitors decrease H2O2 formation by activated human polymorphonuclear leukocytesCarcinogenesis: Integrative Cancer Research, 1987
- C-Myc expression is reduced in antipain-treated proliferating C3H 10T12 cellsBiochemical and Biophysical Research Communications, 1985
- The conditions for the modification of radiation transformation in vitro by a tumor promoter and protease inhibitorsCarcinogenesis: Integrative Cancer Research, 1985
- Trypsin inhibitor activity of conventional foods which are part of the British diet and some soya productsPlant Foods for Human Nutrition, 1981
- Isolation of four soybean trypsin inhibitors by DEAE-cellulose chromatographyBiochemical and Biophysical Research Communications, 1964