The involvement of the enteric nervous system in the intestinal secretion evoked by cyclic adenosine 3‘,5’‐monophosphate
- 1 February 1984
- journal article
- research article
- Published by Wiley in Acta Physiologica Scandinavica
- Vol. 120 (2) , 311-316
- https://doi.org/10.1111/j.1748-1716.1984.tb00139.x
Abstract
Intestinal fluid secretion was evoked in vivo in rats and cats by introducing dibutyryl-cAMP or theophylline, a phosphodiesterase inhibitor, in the intestinal lumen. The intestines were denervated periarterially. Three compounds of varying chemical structure and with different modes of action on nerves (tetrodotoxin, lidocaine, hexamethonium) decreased the secretory response 60-70%. The secretion induced by increasing the intracellular cAMP concentrations is in part evoked via the enteric nervous system.Keywords
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