INFLUENCE OF LOCAL FACTORS ON CUTANEOUS INJURY AND HEALING

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Abstract
IN A PREVIOUS paper1 we made observations on the thresholds of various types of injury to the skin by varying the intensity of a stimulant while keeping constant the site, skin temperature, and blood flow. In the present paper we wish to report on some factors determining the type and severity of reaction, when the injury is to a fixed degree of heat. Clinically, it seems that injuries tend to heal at unequal rates at various sites, an impression we here put to experimental test. We also have examined some factors likely to be responsible. METHOD As in our previous work, we used the Guillemin instrument1 designed for heat conduction by an electrode with a face of 25 sq. mm. and simultaneous indication of temperature and electrical energy necessary to obtain and maintain any given temperature. The subjects were normal volunteers and patients in bed with various

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