Gamma Interferon Synthesis by Human Thymocytes and T Lymphocytes Inhibited by Cyclosporin A
- 1 July 1983
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 221 (4605) , 63-65
- https://doi.org/10.1126/science.6407112
Abstract
Cyclosporin A depresses the synthesis of gamma interferon by human thymocytes and T lymphocytes in vitro. This observation is of potential clinical significance because the long-term treatment of transplant patients with cyclosporin A, a widely used immunosuppressive agent, can give rise to B-cell lymphoma resulting from Epstein-Barr virus activation.This publication has 14 references indexed in Scilit:
- Effect of cyclosporin a on the production of interferon by human peripheral blood leukocytes in vitroAntiviral Research, 1982
- Cyclosporin A – Usefulness, Risks and Mechanism of ActionImmunological Reviews, 1982
- Effect of cyclosporin A on human lymphocyte responses in vitro. IV. Production of T cell stimulatory growth factors and development of responsiveness to these growth factors in CsA-treated primary MLR cultures.The Journal of Immunology, 1982
- Studies on long‐term T‐cell‐mediated immunity to epstein‐barr virus in immunosuppressed renal allograft recipientsInternational Journal of Cancer, 1981
- Liver Transplantation with Use of Cyclosporin a and PrednisoneNew England Journal of Medicine, 1981
- Cyclosporin A blocks receptors for HLA-DR antigens on T cellsNature, 1981
- Cyclosporin A in cadaveric organ transplantation.BMJ, 1981
- Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2European Journal of Immunology, 1981
- EPSTEIN-BARR VIRUS-ANTIBODY RESPONSES AND CLINICAL ILLNESS IN RENAL-TRANSPLANT RECIPIENTS1979
- EFFECTS OF NEW ANTI-LYMPHOCYTIC PEPTIDE CYCLOSPORIN-A IN ANIMALS1977