Immunologic and virologic studies of measles inclusion body encephalitis in an immunosuppressed host
- 1 October 1981
- journal article
- research article
- Published by Wolters Kluwer Health in Neurology
- Vol. 31 (10) , 1263
- https://doi.org/10.1212/wnl.31.10.1263
Abstract
An immunosuppressed child with acute lymphoblastic leukemia in clinical remission developed measles inclusion body encephalitis (MIBE). Although measles antigen and nonbudding measles virus nucleocap-sids were detected in brain tissue, no virus was isolated. Immune precipitation of measles virus proteins with the patient9s serum showed no detectable antibody to virus M protein, a finding that has been reported in subacute sclerosing panencephalitis (SSPE). The virologic and immune precipitation studies suggest a similar virus mutation in MIBE and SSPE. The pathogenesis of the two diseases may also be similar.This publication has 18 references indexed in Scilit:
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