Silylation of Dilute Hydroxy Compounds in Aqueous Solutions
- 1 March 1985
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Chromatographic Science
- Vol. 23 (3) , 128-131
- https://doi.org/10.1093/chromsci/23.3.128
Abstract
A method is described for the preparation of trimethylsilyl ethers of hydroxy compounds at dilute concentrations in aqueous solutions. Silylation with bis-trimethylsilyltrifluoroacetamide (BSTFA) and acetonitrile as a cosolvent yielded quantitative results for various hydroxy compounds. Silylation was complete within 5 min for the compounds tested. This method eliminates tedious removal of water while also producing a single-phase system for chromatographic analysis.Keywords
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