Model independent derivation of general equations for the ?first-pass? effect and extra-hepatic drug elimination
- 1 January 1977
- journal article
- research article
- Published by Springer Nature in European Journal of Clinical Pharmacology
- Vol. 11 (1) , 57-64
- https://doi.org/10.1007/bf00561789
Abstract
A general expression for the ratio of areas below the blood concentration-time curves after intravenous and oral drug administration is derived. This derivation does not require the assumption of a specific compartmental model to describe drug distribution within the body. Similarly an expression for the amount of drug metabolised in the liver is derived. The latter expression is used to estimate the extent of extra-hepatic drug elimination from the body.This publication has 17 references indexed in Scilit:
- A general equation for the ratio of the areas below the blood or plasma concentration time-curves following intravenous and oral drug administration and its application to inter-subject variations in drug elimination.Published by Wiley ,1975
- Derivation of general equations for linear mammillary models when the drug is administered by different routesJournal of Pharmacokinetics and Biopharmaceutics, 1975
- Estimation of biological availability after oral drug administration when the drug is eliminated by urinary excretion and metabolismJournal of Pharmacy and Pharmacology, 1975
- Pharmacokinetic studies on the selectiveβ 1-receptor antagonist metoprolol in manJournal of Pharmacokinetics and Biopharmaceutics, 1974
- Pharmacokinetics of pentazocine in the rhesus monkeyJournal of Pharmaceutical Sciences, 1974
- Effect of route of administration on drug dispositionJournal of Pharmacokinetics and Biopharmaceutics, 1973
- Clearance concepts in pharmacokineticsJournal of Pharmacokinetics and Biopharmaceutics, 1973
- The absorption, blood concentrations and excretion of pentazocine after oral, intramuscular or rectal administration to manJournal of Pharmacy and Pharmacology, 1970
- Pharmacokinetic Basis for the Influence of Route of Administration on the Area Under the Plasma Concentration-Time CurveJournal of Pharmaceutical Sciences, 1969
- Influence of the Route of Administration on the Area Under the Plasma Concentration-Time CurveJournal of Pharmaceutical Sciences, 1969