Minireview: RET: Normal and Abnormal Functions
Open Access
- 1 December 2004
- journal article
- review article
- Published by The Endocrine Society in Endocrinology
- Vol. 145 (12) , 5448-5451
- https://doi.org/10.1210/en.2004-0922
Abstract
The RET gene encodes a single-pass transmembrane receptor tyrosine kinase. RET is the oncogene that causes papillary thyroid carcinoma and medullary thyroid carcinoma. The latter may arise as a component of multiple endocrine neoplasia type 2 syndromes; germline mutations in RET are responsible for multiple endocrine neoplasia type 2 inheritance. In this report we review data on the mechanisms leading to RET oncogenic conversion and on RET targeting as a strategy in thyroid cancer treatment.Keywords
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