Further Studies on the Mechanism of Fat-Free Diet (FFD)--Protection against Indomethacin-Induced Intestinal Ulcers in the Rat

Abstract
A fat-free diet (FFD) reduces bacterial flora when compared to a regular diet (RD) in rats. FFD reduces the degree of incidence of indomethacin-induced intestinal ulceration concomitantly with a reduction in bacterial flora overgrowth produced by the drug. Diminished deconjugation of indomethacin and reduction of intestinal flora overgrowth play a major role in the ulcer-preventing properties of FFD.

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