Mobilization of Lead by Calcium Disodium Edetate

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Abstract
The clinical use of the diagnostic calcium disodium edetate mobilization test for lead in both children and adults has increased substantially in recent years. Indeed, it has been proposed that this test be used whenever chelation therapy is contemplated in children with blood lead levels in the range of 1.21 to 2.65 μmol/L (25 to 55 μg/dL) and an elevated erythrocyte protoporphyrin level. Selection of cases for a therapeutic course of chelation would depend on the result of the test. In this issue ofAJDC, Weinberger and associates1analyze their experience between 1972 and 1982 with an eight-hour mobilization test carried out in an ambulatory setting and suggest that the current parameters be modified somewhat. Irrespective of the mechanics of the test and its clinical interpretation, some fundamental toxicologic issues merit serious consideration. Where does the lead come from and where does it go when a metal-binding agent such as

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