Synthesis of 6-N-Biotinylaminohexyl Isopropyl Phosphorofluoridate: A Potent Tool for the Inhibition/Isolation of Serine Esterases and Proteases
- 1 March 1999
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1999 (03) , 407-409
- https://doi.org/10.1055/s-1999-3419
Abstract
6-N-Biotinylaminohexyl isopropyl phosphorofluoridate 2 was prepared by treatment of the corresponding hydrogen phosphonic diester with triethylamine trihydrofluoride and iodine. The activity of the phosphorofluoridate was tested by the inhibition of a-chymotrypsin.Keywords
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