URIC ACID METABOLISM IN PSORIASIS

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Abstract
Nineteen of 38 patients with psoriasis were found to have an associated elevation of the serum uric acid. Patients with extensive skin involvement tended to have a higher incidence of hyperuricemia. Five patients with psoriasis all showed a greater than normal incorporation of glycine-1-C-14 into urinary uric acid. The pattern of incorporation of C14 into urinary acid tended to differ from what seen in control subjects and appeared to be intermediate between that shown by patients with primary gout and those with secondary gout. This suggests that the abnormality in uric acid metabolism in psoriasis may, in part, be related to a more rapid turnover of nucleic acids involved in the process of accelerated epidermal proliferation that occurs in this disease. The abnormal labeling of urinary uric acid returned to normal after clinical remission of psoriasis in one patient.