MANAGEMENT OF PELVIC COMPLICATIONS OF MALIGNANT UROTHELIAL TUMORS WITH COMBINED INTRA-ARTERIAL AND IV-CHEMOTHERAPY

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 66  (7) , 1501-1507
Abstract
Twenty-nine patients with local-regional pelvic recurrences of malignant urothelial tumors were treated with combined intra-arterial and i.v. chemotherapy. 5-FU [5-fluorouracil] (1 g/m2) was infused daily for 5 days via bilateral percutaneously placed hypogastric catheters. Doxorubicin (25 mg/m2) was infused i.v. on days 1 and 2 and mitomycin (5 mg/m2) was infused i.v. on days 3 and 4 of each course. Seventeen patients (58%) demonstrated an objective decrease in the size of the pelvic mass. All 4 patients with 1 of the adenocarcinoma variants of malignant urothelial tumors responded to therapy; the 3 patients with squamous transformation of a transitional cell carcinoma failed to respond. The median survival of the responding patients was significantly longer (52 wk) than that of nonresponding patients (28 wk) (P = 0.002). Patients with initial low-volume pelvic disease demonstrated durable control of local residual tumors, with 4 of 6 patients having negative repeat cystoscopic examinations.