FURTHER STUDIES ON THE EFFECTS OF ADRENAL MEDULLARY HORMONES ON RENAL EXCRETION OF WATER AND ELECTROLYTES IN THE INTACT RAT1
- 1 October 1954
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 55 (4) , 448-455
- https://doi.org/10.1210/endo-55-4-448
Abstract
Based upon dose-response curves, the data presented favor the view that the adrenal medullary hormones have a qualitatively similar action, but differ quantitatively, in enhancing water, Na, and Cl output and K retention during water diuresis in the rat. Hormone dosages which are effective in the above mentioned respects in hydrated rats are also effective in non-hydrated rats. The hormones also increase urine output in water-fasted rats. Aqueous norepinephrine is diuretic and chloruretic when given intravenously in a dose of 10 [mu]g/rat. Under the conditions of this experiment its natriuretic and K retaining properties were not demonstrated. The intact rat allowed food and water ad libitum and injected for 7 days with norepinephrine (50 [mu]g/100 gm/day) failed to show changes in water intake and urine output but tended to excrete Na and Cl and retain K.Keywords
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