Dose-response study of ivermectin against Dirofilaria immitis microfilariae in dogs with naturally acquired infections

Abstract
SUMMARY: In dogs, ivermectin given as a single oral dose 6 weeks after they were treated with thiacetarsamide was highly efficacious against the microfilariae of Dirofilaria immitis. A dose of 0.2 mg of ivermectin/kg of body weight or 1 dose of 0.05 mg/kg appeared to completely clear microfilariae from the blood. A dose of 0.0125 mg/kg cleared microfilariae from 2 of 3 dogs, and even a dose of 0.00313 mg/kg resulted in substantial reduction of the microfilaremia.

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