The Cytolysis of Human Neuroblastoma Cells by a Natural IgM ‘Antibody’-Complement System in Pregnancy Serum
- 1 January 1990
- journal article
- Published by Taylor & Francis in Cancer Investigation
- Vol. 8 (6) , 603-611
- https://doi.org/10.3109/07357909009018927
Abstract
Cell lines from 26 human cancers were studied for cytotoxicity when treated with normal pregnancy serum. Cytotoxicity manifested by cell death and cytolysis, occurred in 4 of 8 neuroblastomas studied: SK-N-SH, NGP, LAN-5, and IMR-32. In NGP and SK-N-SH, evidence is presented showing that the cytotoxicity resulted from the cell-surface binding of a natural IgM 'antibody', which sensitized the neuroblastoma cells to the lytic action of complement (C). This system may be involved in a cytolytic form of spontaneous regression of neuroblastoma.Keywords
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