Activation and repression of transcription by homoeodomain-containing proteins that bind a common site
- 29 December 1988
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 336 (6201) , 744-749
- https://doi.org/10.1038/336744a0
Abstract
The product of the fushi tarazu (ftz) gene is shown to be a site-dependent activator of transcription. In vitro-defined binding sites act as ftz-dependent enhancers in cultured cells. Another homoeodomain-containing protein, the engrailed gene product, competes for homoeodomain-binding sites and counteracts ftz activation.Keywords
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