LEUCINE AMINOPEPTIDASE IN THE DEVELOPING TEETH OF THE MOUSE

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Abstract
Leucine aminopeptidase in the dental germs and teeth of mice was absent in the earliest evolutionary stages and did not appear until the "bell stage" of the enamel organ in the outer enamel epithelium and the dental sack. When the ameloblasts and odontoblasts began to function actively, a strong positive reaction appeared in these cells and in Tomes'' processes and fibers. A very intensive reaction occurred concurrently in the cells of the stratum-intermedium and the sub-odontoblast cell layer. The cells of the stellate reticulum and the pulp were negative. On the other hand, a reaction of moderate intensity was encountered in the pulp of the steadily growing incisors. The mesenchymal cells of the gingiva gave an irregular positive reaction, and the gingival mast cells were positive. A fairly intense reaction was demonstrated in the basal parts of the gingival mucosa. Its occurrence illustrates metabolic activity, and it is of significance for the formation of matrix of enamel and dentine.

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