Reassessing the amyloid cascade hypothesis of Alzheimer's disease
Top Cited Papers
- 30 December 2008
- journal article
- review article
- Published by Elsevier in The International Journal of Biochemistry & Cell Biology
- Vol. 41 (6) , 1261-1268
- https://doi.org/10.1016/j.biocel.2008.12.015
Abstract
No abstract availableKeywords
This publication has 88 references indexed in Scilit:
- Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memoryNature Medicine, 2008
- β‐amyloid burden is not associated with rates of brain atrophyAnnals of Neurology, 2008
- Rapid appearance and local toxicity of amyloid-β plaques in a mouse model of Alzheimer’s diseaseNature, 2008
- Plaque-bearing mice with reduced levels of oligomeric amyloid-β assemblies have intact memory functionNeuroscience, 2007
- Putting presenilins centre stageEMBO Reports, 2007
- Loss‐of‐function presenilin mutations in Alzheimer diseaseEMBO Reports, 2007
- When loss is gain: reduced presenilin proteolytic function leads to increased Aβ42/Aβ40EMBO Reports, 2007
- The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanismProceedings of the National Academy of Sciences, 2007
- BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic miceNeurobiology of Disease, 2006
- PS1 activates PI3K thus inhibiting GSK-3 activity and tau overphosphorylation: effects of FAD mutationsThe EMBO Journal, 2004