Conformation of two somatostatin analogues in aqueous solution
- 1 November 1989
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 185 (2) , 371-381
- https://doi.org/10.1111/j.1432-1033.1989.tb15125.x
Abstract
Cyclic-disulfide-containing analogues of somatostatin, Xaa1-Cys2-Xaa3-DTrp4-Lys6-Thr5-Xaa7-Xaa8 [Xaa1 = H or DPhe; Xaa3 = Phe or Tyr; Xaa7 = Cys, Me2DCys; Xaa7 = OH, Thr8 (OH) or Thr8NH2], were examined in aqueous solution by 1H-NMR spectroscopy and circular dichroism. The influence of the helical nature of the disulfide bridge and the presence of exocyclic residues on biological activity were investigated with particular care.This publication has 51 references indexed in Scilit:
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