Antagonism of Excitatory Amino Acid‐Induced and Synaptic Excitation of Spinal Neurones by cis‐2,3‐Piperidine Dicarboxylate

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Abstract
In tests on neurones in the cat spinal cord in vivo, and frog and immature rat spinal cord in vitro, cis‐2,3‐piperidine dicarboxylate (cis‐2,3‐PDA) produced the following effects: (1) selective antagonism of amino acid‐induced responses, compared with responses to other putative transmitters; (2) effective antagonism of kainate and quisqualate‐induced responses in addition to responses induced by N‐methyl‐D‐aspartate (NMDA) and other excitatory amino acids; (3) partial NMDA‐like agonist action; (4) antagonism of dorsal root‐evoked excitation of Renshaw cells; (5) potentiation of acetylcholine‐ and ventral root‐evoked excitation of Renshaw cells. This unique spectrum of action may be useful for transmitter receptor characterization in the vertebrate central nervous system.