Highly Potent Chiral Labeling Reagents for the Discrimination of Chiral Alcohols
Open Access
- 2 September 2003
- journal article
- Published by Springer Nature in Analytical Sciences
- Vol. 19 (9) , 1243-1249
- https://doi.org/10.2116/analsci.19.1243
Abstract
Highly sensitive chiral labeling reagents, (1R,2R)- and (1S,2S)-2-(2,3-anthracenedicarboximido)cyclohexanecarboxylic acids [(1R,2R)- and (1S,2S)-A] and (1R,2R)- and (1S,2S)-2-(2,3-naphthalenedicarboximido)cyclohexanecarboxylic acids [(1R,2R)- and (1S,2S)-A′], were prepared. Reagent A has enabled us to discriminate the enantiomers of anteiso fatty alcohols up to C9 methyl branching by 1H NMR, and both reagents A and A′ have allowed up to C16 methyl branching at the 10-15 molar level by fluorescence detected reversed-phase HPLC.Keywords
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