The application of biofilm science to the study and control of chronic bacterial infections
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Open Access
- 15 November 2003
- journal article
- Published by American Society for Clinical Investigation in Journal of Clinical Investigation
- Vol. 112 (10) , 1466-1477
- https://doi.org/10.1172/jci200320365
Abstract
Unequivocal direct observations have established that the bacteria that cause device-related and other chronic infections grow in matrix-enclosed biofilms. The diagnostic and therapeutic strategies that have served us so well in the partial eradication of acute epidemic bacterial diseases have not yielded accurate data or favorable outcomes when applied to these biofilm diseases. We discuss the potential benefits of the application of the new methods and concepts developed by biofilm science and engineering to the clinical management of infectious diseases.Keywords
This publication has 55 references indexed in Scilit:
- Detection ofStaphylococcus aureusBiofilm on Tampons and Menses ComponentsThe Journal of Infectious Diseases, 2003
- Use of the Quorum‐Sensing Inhibitor RNAIII‐Inhibiting Peptide to Prevent Biofilm Formation In Vivo by Drug‐ResistantStaphylococcus epidermidisThe Journal of Infectious Diseases, 2003
- Listening in on bacteria: acyl-homoserine lactone signallingNature Reviews Molecular Cell Biology, 2002
- Candidate's Thesis: Direct Evidence of Bacterial Biofilms in Otitis MediaThe Laryngoscope, 2001
- Natural conjugative plasmids induce bacterial biofilm developmentNature, 2001
- Liquid flow in heterogeneous biofilmsBiotechnology & Bioengineering, 1994
- Bacterial invasion of the biliary system by way of the portal-venous systemHepatology, 1991
- Foreign-Body-Associated Experimental Osteomyelitis Induced With Bacteroides fragilis and Staphylococcus epidermidis in RabbitsClinical Orthopaedics and Related Research, 1991
- Bacterial Biofilms in Nature and DiseaseAnnual Review of Microbiology, 1987
- A scanning and transmission electron microscopic study of an infected endocardial pacemaker lead.Circulation, 1982