HLA associations in insulin‐dependent diabetes: search for heterogeneity in different groups of patients from a homogeneous population
- 1 October 1986
- journal article
- research article
- Published by Wiley in Tissue Antigens
- Vol. 28 (4) , 237-244
- https://doi.org/10.1111/j.1399-0039.1986.tb00489.x
Abstract
A total of 317 unrelated Danish patients with insulin‐dependent diabetes mellitus (IDDM) have been HLA‐DR typed and the antigen and phenotype frequencies compared with those in 1177 unrelated Danish controls. The strong positive associations with DR3 and 4 and the strong negative one with DR2 were confirmed, and the remaining antigens showed a hierarchy from weakly positive to strongly negative associations: DRw9, w8, 1, 5, w6, 7. The study population included various special groups of patients selected in order to study heterogeneity: very early (< 5 years) and very late (> 40 years) onset IDDM, pregnancy induced IDDM, IDDM nephropathy, and long‐term (> 40 years) survivors without complications. When comparing these groups, the following minor differences were seen: the DR3,4 phenotype is significantly (p = .02) more frequent in IDDM with onset before age 20 (35%) than in other cases (24%), and in familial IDDM (48%) than in other cases (28%); the frequency of the DR4 antigen was significantly (p = .008) more frequent in long‐term survivors (86%) than in other patients (69%), while it was significantly (p = .02) less frequent in IDDM nephropathy (63%) than in long‐term survivors. However, apart from the age‐at‐onset heterogeneity, which was suspected a priori, these differences may be due to chance, and the main conclusion of this study is that the HLA‐DR associations in IDDM are indeed extraordinarily homogeneous irrespective of the clinical characteristics at onset and course of the disease.This publication has 22 references indexed in Scilit:
- DNA Polymorphism of HLA Class I and Class II RegionsImmunological Reviews, 1985
- A family study of the association between insulin dependent diabetes mellitus, autoantibodies and the HLA systemTissue Antigens, 1984
- HLA-D region β-chain DNA endonuclease fragments differ between HLA-DR identical healthy and insulin-dependent diabetic individualsNature, 1983
- The epidemiologic approach to studies of association between HLA and disease: II. Estimation of absolute risks, etiologic and preventive fractionTissue Antigens, 1982
- The epidemiologic approach to studies of association between HLA and disease:I. The basic measures, concepts and estimation proceduresTissue Antigens, 1982
- Genetic studies of insulin-dependent diabetes mellitus: segregation and linkage analysesTissue Antigens, 1982
- HLA-A, -B, and -DR associations in type I diabetes mellitus with onset after age fortyDiabetes, 1982
- HLA-DR phenotype and HLA-B,DR haplotype frequencies in 704 unrelated DanesTissue Antigens, 1981
- HLA-DR genes and antigens in the Danish population.Tissue Antigens, 1981
- ON ESTIMATING THE RELATION BETWEEN BLOOD GROUP AND DISEASEAnnals of Human Genetics, 1955