Acute Onset Deafness in a 4-Year-Old Girl After a Single Infusion of Cis-Platinum
- 1 January 1990
- journal article
- other
- Published by Taylor & Francis in Pediatric Hematology and Oncology
- Vol. 7 (2) , 145-148
- https://doi.org/10.3109/08880019009033384
Abstract
Dose-dependent reduction of auditory Junction mainly in the high frequency range has been described as a common adverse side effect of cis-platinum. Here we report on a 4-year-old girl with osteosarcoma of the right distal femur who developed acute bilateral deafness 3 days after a single infusion of high-dose cis-platinum (150 mg/m2) during preoperative chemotherapy. Sudden disabling ototoxicity should be considered when administering high-dose cis-platinum to young children.Keywords
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