Intercellular contacts between migrating blood cells and cells of the sinusoidal wall of bone marrow. An ultrastructural study using tannic acid

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Abstract
The migration of blood cells across the sinusoidal wall of murine bone marrow was studied following fixation with tannic acid‐glutaraldehyde. Electron microscopic examination showed regions of close membrane apposition (referred to in this study as “intercellular contacts”) between migrating blood cells and cells of the sinusoidal wall (adventitial and endothelial cells). Ultrastructurally the intercellular contacts are pentalaminar structures resembling gap junctions of other organs after tannic‐acid fixation. The possibility that these contacts are regions of intercellular communication and/or sites of membrane attachment utilized for locomotion of the migrating blood cells is discussed.