Inhibition of the Late Phase Reaction to Anti‐IgE by Previous Mast Cell Activation with Compound 48/80
- 1 February 1984
- Vol. 39 (2) , 119-123
- https://doi.org/10.1111/j.1398-9995.1984.tb01943.x
Abstract
The concept of an obligate association between mast cell activation and development of a late phase reaction (LPR) to various agents in human skin was further elucidated. Skin sites were treated four times at 24 h intervals with non‐LPR‐inducing doses of the histamine liberator compound 48/80 in 10 volunteers. The previously compound 48/80‐challenged sites responded with an approximately 40% attenuated early response (P < 0.01) and a 70% reduction of the LPR (P < 0.001) to subsequently injected anti‐IgE as compared with simultaneous reactions at control sites The data suggest that mediators from the cutaneous mast cells are necessary for the final expression of an LPR.Keywords
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