α- and β-Adrenoceptor Blockade Fail to Prevent High Sodium Diet-Induced Left Ventricular Hypertrophy

1 August 1997

journal article
Published by Oxford University Press (OUP) in American Journal of Hypertension

Vol. 10 (8) , 913-920
https://doi.org/10.1016/s0895-7061(97)00120-9

Abstract

High sodium diet (HS, 8% NaCl) induces left ventricular hypertrophy (LVH) in normotensive rats without an increase in pressure or volume load or in resting cardiac sympathetic activity. HS may affect LV adrenoceptors density or affinity or their postreceptor pathways, thereby causing LVH. We therefore assessed the effects of HS with and without blockade of α₁- or β-adrenoceptors by terazosin or nadolol, alone or in combination, on resting hemodynamics, LV and right ventricular (RV) weights, and LV dimensions of male WKY rats.

Keywords

HEMODYNAMICS
END DIASTOLIC PRESSURE
RIGHT ATRIAL PRESSURE

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