Azo Reduction of Salicyl-Azo-Sulphapyridine in Germ-free and Conventional Rats

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Abstract
1. Salicyl-azo-sulphapyridine was recovered mainly as azo-cleavage products in conventional rats after oral as well as after intraperitoneal administration of the drug. 2. After administration of salicyl-azo-sulphapyridine to germ-free rats, the recovery of azo-cleavage products was 1·7% of the dose after oral and 10% of the dose after intraperitoneal dosage. 3. It is concluded that salicyl-azo-sulphapyridine is reductively cleaved at the azo linkage by the action of the intestinal microflora and that azo-reductases in the tissues play a minor role.