Metabolic investigations in Menière's disease

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Abstract
Patients (27) (15 male:12 female) with Meniere''s disease who conformed to the criteria set out by the Committee of Hearing and Equilibration of the American Academy of Ophthalmology and Otolaryngology were studied. In this series the incidence of abnormal metabolic states was no higher than in a comparable group from the general population. No significant difference existed in response to pin prick skin tests when allergic response compared with a control group. Klockhoff and Lindblom''s glycerol dehydration test was applied to 21 patients. Changes in the osmolality of the serum, the pure tone threshold of hearing and the maximum speech discrimination score were measured. Continuous transtympanic electrocochleographic recordings during glycerol dehydration were performed. In 10 patients a definite decrease existed in the negative summating potential. An electrophysiological explanation is presented and the possible use of this measurement in the diagnosis and management of Meniere''s disease is discussed.

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