Bone Changes in Oophorectomized Monkeys

Publisher Website
Google Scholar
Abstract
Single and dual energy CT (75 and 125 kVp) measurements of density were made on the excised lumbar vertebrae (L5) of oophorectomized (n = 17) and control (n = 19) monkeys. The single-energy results at 75 and 125 kVp indicated an annual bone diminution of 9.1 and 10.9%, respectively, but the dual-energy determination showed only a 6.6%/year loss. The difference between single- and dual-energy results could be explained by a putative increase in marrow fat of slightly > 100 mg/cm3. Changes in single-energy CT density with oophorectomy and aging may be substantially overestimated.