HEPARIN-BINDING FRAGMENTS OF FIBRONECTIN ARE POTENT INHIBITORS OF ENDOTHELIAL-CELL GROWTH
- 1 January 1985
- journal article
- research article
- Vol. 120 (3) , 327-332
Abstract
Two heparin-binding proteolytic fragments of fibronectin- an amino-terminal 29-kd segment and a carboxyl-terminal 40-kd segment-are apparently specific, potent inhibitors of the growth of cultured bovine aortic endothelial cells and inhibit growth in a reversible, dose-dependent manner. In contrast, native fibronectin at higher dosages neither inhibits, nor interferes with the effects of the 29-kd fragment. The data, therefore, suggest that fibronectin fragments may participate in the regulation of vascular growth.This publication has 32 references indexed in Scilit:
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