Inhibition of Platelet Aggregation by Shikonin Derivatives Isolated fromArnebia euchroma
- 1 October 1993
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 59 (05) , 401-404
- https://doi.org/10.1055/s-2006-959718
Abstract
Four antiplatelet components were isolated from Arnebia euchroma. They inhibited the aggregation of washed rabbit platelets caused by collagen, arachidonic acid, platelet-activating factor, ADP, or thrombin. The potency of inhibiting collagen-induced platelet aggregation is in the following order: acetyl-shikonin (IC50 = 2.1 µM), teracrylshikonin (2.8 µM), β,β-dimethylacrylshikonin (4.2 µM), and shikonin (10.7 µM). In rat aorta, acetylshikonin and shikonin inhibited high potassium and norepinephrine-induced contractions, while β,β-dimethylacrylshikonin and teracrylshikonin potentiated the phasic contraction caused by norepinephrine.Keywords
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