Electronic absorption and electron spin resonance studies on the interaction between the biologically relevant copper(II) glycylglycine and L-histidine complexes with D-penicillamine
- 1 January 1975
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in J. Chem. Soc., Dalton Trans.
- No. 14,p. 1389-1394
- https://doi.org/10.1039/dt9750001389
Abstract
The ternary systems CuII+ Gly-Gly +D-penicillamine, and CuII+L-His +D-penicillamine, were examined in neutral aqueous solutions by electronic absorption and e.s.r. spectroscopy. The Gly-Gly system was further examined by circular dichroism and electrophoresis measurements. The results are compared with those from the binary system CuII+D-penicillamine, and with the ternary systems where L-cysteine or dimercaptopropanol replace D-penicillamine. Evidence is presented for the formation of dimeric ternary complexes in the Gly-Gly and L-His systems at concentrations of Cu : Pen < 1 : 2. The relevance of the ternary complexes to the mode of mobilisation of the excess copper in Wilson's disease is discussed.Keywords
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