Increased Myocardial Contractility in Young Newly Diagnosed Type 1 (Insulin-Dependent) Diabetics Free of Diabetic Complications: An Echocardiographie Study

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Abstract
One hundred and fifty-seven young cardiac asymptomatic type 1 diabetics and 54 control subjects were examined with M-mode echocardiography to elucidate the early changes in left ventricular systolic function (LVSF) in diabetes mellitus. Out of 157 diabetics a group of 40 newly diagnosed diabetics without diabetic complications was formed (retinopathy, nephropathy, autonomic neuropathy). They had ejection fraction (71.3 ± 3.3%), fractional shortening (FS = 40.5 ± 2.3%) and corrected mean velocity of circumferential fiber shortening (1.23 ± 0.11 circ/s) significantly higher than those of the control subjects (65.7 ± 3.0, 36.3 ± 2.3, 1.08 ± 0.09), but end-diastolic volume index (as preload, 72.9 ± 11.7 ml/m2), end-systolic meridional wall stress (MWSs, as afterload, 65.7 ± 12.4kdyn/cm2) and heart rate (HR = 72.8 ± 10.0 bpm) were unchanged significantly compared to the control values (68.6 ± 10.8, 70.9 ± 15.0, 74.4 ± 11.0). In 90% of the newly diagnosed diabetics the FS was above the 95% confidence limits of the control FS/MWSs relation, on the background of a significant difference (p

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