Polymorphonuclear Leukocytes in Antibody-Dependent Cellular Cytotoxicity
Open Access
- 1 March 1975
- journal article
- Published by Oxford University Press (OUP) in The Journal of Immunology
- Vol. 114 (3) , 1047-1051
- https://doi.org/10.4049/jimmunol.114.3.1047
Abstract
Human polymorphonuclear leukocytes (PMN) lyse antibody-coated target cells in an immunologically specific fashion—antibody-dependent cellular cytotoxicity (ADCC). PMN-mediated cytolysis is independent of complement, de novo protein synthesis, and DNA replication. Cytolysis is rapid, detectable at low PMN:target cell ratios, and exceeds lymphocyte-mediated ADCC. The interaction appears to be mediated via an Fc receptor and is inhibited by aggregated γ-globulin. A role for PMN in host tumor cell immunity is discussed.Keywords
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