Persistent bipolar illness after steroid administration

Abstract
A 28 yr old woman received a single course of corticosteroids for treatment of ulcerative colitis. She became depressed; shortly thereafter, signs of mania developed. Despite discontinuation of corticosteroid therapy, the patient had 5 bouts of mania, closely followed by severe depression, in the past 1 1/2 yr. This was the 1st case of persistent bipolar illness after exogenous steroid administration.

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