EFFECTS OF PHENOTHIAZINE ON HORSES I. STUDIES IN HAEMATOLOGY AND PHARMACOLOGY

Publisher Website
Google Scholar
Abstract
Studies have been made on the anaemia and cythaemolytic icterus produced by 60 and 70 gm. doses of phenothiazine to horses weighing approximately 1200 lb. The continued and prolonged haemolytic effect of a single dose may be serious in a horse having a large proportion of microcytic erythrocytes. No evidence of damage to the liver was obtained, but clinical observations confirm a previous report that severe injury to the urinary system may result from a dose of 60 gm. of phenothiazine to a 1200 lb. horse.A dose of 30 gm. removed all the strongyloid nematodes and did not cause haemolysis. Less than half the dose could be recovered from the excreta of treated animals. The effects of phenothiazine on horses are similar to those of sulphanilamide and sulphapyridine in susceptible humans. The possibility of over-stimulation of the spleen with the consequent hyperactivity causing prolonged haemolysis is mentioned.

This publication has 0 references indexed in Scilit: