ADENYLATE CYCLASE ACTIVITY IN MOUSE VAGINAL EPITHELIUM. AGE RELATED CHANGES IN BASAL ENZYME ACTIVITY AND ESTRADIOL SENSITIVITY

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Abstract
Using neonatal and immature female NMRI mice, age related variations in histochemically demonstrable adenylate cyclase activity were studied in the vaginal epithelium. Basal enzyme activity increased from day 3 to 6 after birth, only later to decrease. Almost no activity was seen on day 14. An estradiol induced increase in enzyme activity occurred in 3 and 6 day old animals but not in 14 day old animals. Despite this difference, neonatal and 14 day old animals respond to estradiol with an increased amount of a cellular product with antigenic properties specific for the cervicovaginal epithelium. The results are discussed in relation to estrogen induced irreversible effects in the neonatal cervicovaginal epithelium.