A Practical Six-Step Synthesis of (S)-Camptothecin
- 22 November 2001
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 3 (26) , 4255-4257
- https://doi.org/10.1021/ol0169271
Abstract
An asymmetric synthesis of (S)-camptothecin (1) has been accomplished in six steps starting from two commercially available heterocycles.Keywords
This publication has 12 references indexed in Scilit:
- Convergent catalytic asymmetric synthesis of camptothecin analog GI147211CTetrahedron, 1997
- Asymmetric synthesis of a key camptothecin intermediate from 2-fluoropyridineTetrahedron Letters, 1995
- A Six-Step Synthesis of (.+-.)-CamptothecinThe Journal of Organic Chemistry, 1994
- Asymmetric synthesis of camptothecin alkaloids: A nine-step synthesis of (S)-camptothecinTetrahedron Letters, 1994
- A 10-step, asymmetric synthesis of (S)-camptothecinJournal of the American Chemical Society, 1992
- Lithiation of methoxypyridines directed by .alpha.-amino alkoxidesThe Journal of Organic Chemistry, 1990
- Asymmetric synthesis of (S)-camptothecinTetrahedron Letters, 1989
- Ortho lithiation of 2-, 3-, and 4-methoxypyridinesTetrahedron Letters, 1988
- Synthesis of benzyl halides from aldehydes promoted by halosilanes and 1,1,3,3-tetramethyldisiloxane (TMDS).Tetrahedron Letters, 1984
- Plant Antitumor Agents. I. The Isolation and Structure of Camptothecin, a Novel Alkaloidal Leukemia and Tumor Inhibitor from Camptotheca acuminata1,2Journal of the American Chemical Society, 1966