HIGH FREQUENCY OF Mlsa‐REACTIVITY AMONG Ab‐RESTRICTED, H‐Y‐SPECIFIC T CELL CLONES
- 1 February 1988
- journal article
- Published by Wiley in International Journal of Immunogenetics
- Vol. 15 (1-3) , 101-109
- https://doi.org/10.1111/j.1744-313x.1988.tb00412.x
Abstract
A high frequency (80%) of Ab-restricted, H-Y-specific T cell clones, but not of Ab-restricted LDH-B-specific T cell clones, was found to be Mlsa-reactive. This reactivity could be inhibited by class II (A and E)-specific antibodies, and required an E-positive stimulator cell. The proliferation was also blocked by T cell receptor-specific and by CD4-specific antibodies. Possible interpretations of these findings are discussed.Keywords
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