Differential expression of type I insulin‐like growth factor receptors in different stages of human T cells

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Abstract
Insulin‐like growth factor I (IGF‐I) has been implicated to play a regulatory role in T cell development and in T cell function. We investigated the expression of type I IGF receptors on human peripheral T cells related to the maturation and activation stage using the type I IGF receptor‐specific monoclonal antibody αIR3. It appeared that 87% of the CD4+CD45RA+ cells and 66% of the CD8+CD45RA+ cells were αIR3+, whereas only 37% of the CD4+CD45RO+ cells and 38% of the CD8+CD45RO+ cells bound αIR3. We also found that the fraction of αIR3+ cells within in vivo or in vitro activated (HLA‐DR+) T cells is markedly lower than in nonactivated (HLA‐DR−) cells. In vitro phytohemagglutinin‐activated T cells and CD4+CD45RO+ cells activated with recall antigens also contained less αIR3+ cells (1–6%) than nonactivated cells (30–54%).