Possible Role of Histamine in Rheumatoid Arthritis.
- 1 August 1981
- Vol. 36 (6) , 435-436
- https://doi.org/10.1111/j.1398-9995.1981.tb01852.x
Abstract
Basophilocytes from patients with rheumatoid arthritis (RA) responded to leukocyte nuclei from normal persons with histamine release; a similar histamine release induced by the nuclear components RNA and DNA was demonstrated previously. A role of histamine in RA is also supported by the findings of clinical improvement during treatment with H1 and H2 antihistamines [cimetidine, mepyramine] in 6 of 12 patients with RA in active phase, whereas 4 showed definite deterioration.Keywords
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