Water and Electrolyte Pharmacodynamics of Aspirin.
- 1 April 1962
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 109 (4) , 824-826
- https://doi.org/10.3181/00379727-109-27347
Abstract
The effect of aspirin (10 mg/kg. per os) on urinary volume, Na+ and K+ as well as thiocyanate space was studied in mice with and without infection from influenza virus (type A PR-8). Infection reduced urine volume and Na+ but increased urine K+ and was without effect on thiocyanate space. Aspirin reduced urine volume, Na+ and K+ and in addition decreased the thiocyanate space in the infected animals. Evidently aspirin activated mechanisms in the infected animals that favored expansion of the ihtracellular fluid volume at the expense of the extracellular fluid.Keywords
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