In Vivo Platelet Hyperactivity and Factor VIII Related Antigen Increase Long after Myocardial Infarction

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Abstract
In the Anturane Reinfarction Italian Study the trend of some specific and quantitative hemostatic parameters is being investigated in different series of patients balanced for sulfinpyrazone and placebo. In a series of young male patients who had had myocardial infarction 6 mo. previously, the placebo treatment subsample presented shortened platelet production time (PPT), increased levels of plasma .beta.-thromboglobulin (.beta.-TG) and platelet factor 4 (PF4), and increased factor VIII related antigen (VIII:RAg) compared with a matched control group. A close correlation between plasma concentration of VIII:RAg and PPT was evidenced in the same treatment subsample. The sulfinpyrazone treatment subsample presented normalized PPT accompanied by reduction of VIII:RAg but not of .beta.-TG or PF4 levels.