Cardiovascular Morbidity and Mortality in Type 2 Diabetic Patients: a 22‐year Historical Cohort Study in Dutch General Practice

Publisher Website
Google Scholar
Abstract
A historical cohort study was performed to assess cardiovascular morbidity and mortality in Type 2 (non‐insulin‐dependent) diabetic patients. The data were collected from 1967 to 1989 in four Dutch general practices performing the Continuous Morbidity Registration Nijmegen. Each newly diagnosed Type 2 diabetic patient fulfilling the WHO criteria (n = 265) was matched to a control patient for practice, sex, age, and social class. Inclusion started in 1967, the first year of the still ongoing, Continuous Morbidity Registration Nijmegen. On average, a follow‐up of 6.8 years (range 1 month—22 years) was realized. Compared to the non‐diabetic control patients, the Type 2 diabetic patients showed higher cardiovascular morbidity (risk ratio 1.76, 95 % CI 1.34–2.30) and a higher mortality rate (risk ratio 1.54, 95 % CI 1.07–2.23). Mortality after 10 years was 36 % vs 20 % (p < 0.01), the median survival time 16 years vs 19 years. The cumulative survival rates were significantly different (p < 0.01) between patients and controls in the age group 65–74 years. The higher mortality in Type 2 diabetic patients was completely due to an excess of cardiovascular death (risk ratio 2.05, 95 % CI 1.24–3.37).