PSEUDO-CHEDIAK-HIGASHI ANOMALY IN A CASE OF ACUTE MYELOID-LEUKEMIA - ELECTRON-MICROSCOPIC STUDIES

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 54  (4) , 863-871
Abstract
Formation and fine giant granule structure in neutrophil promyelocytes of a patient with a variant of acute myelogenous leukemia were investigated by EM. The patient presented with large lymph nodes and disseminated intravascular coagulation (DIC). By light microscopy, numerous giant granules resembling those of Chediak-Higashi syndrome (CHS) were present, but Auer bodies could not be found. By EM, these giant granules were formed by azurophilic granule fusion as in CHS; they differed from large CHS granules, since they contained numerous microcrystalline structures like those of Auer bodies. Crystalline cores of these granules exhibited periodicity different from that of Auer bodies of acute promyelocytic leukemia. This clinical and hematologic syndrome (giant granules, enlarged lymph nodes and DIC) may represent an acute promyelocytic leukemia variant.