Detection of the granulocyte‐specific antigen 3‐fucosyl‐N‐acetyl‐lactosamine on leukemic cells after neuraminidase treatment

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Abstract
The carbohydrate antigen 3‐fucosyl‐N‐acetyl‐lactos‐amine (FAL) is expressed on human granulocytes and is detected by a monoclonal antibody B4.3. After neuraminidase treatment, this structure can also be detected on monocytes and on the cells of nearly all acute myeloid leukemia patients (38/39). It is then also present on the cells of a number of CALLA‐positive lymphatic leukemias (8/18), but not on T‐ALL and B‐ALL cells. On cells of patients with AUL, the antigen is then detected in many TdT+ cases, but not in TdT− cases.

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